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Article

Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.

Pancreas - 1 Mar 2008

Baker Amanda F, Koh Mei Y, Williams Ryan R, James Brian, Wang Huamin, Tate Wendy R, Gallegos Alfred, Von Hoff Daniel D, Han Haiyong, Powis Garth

Abstract excerpt

OBJECTIVE: To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS: MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measured after growth in normoxia or hypoxia. In addition, HIF-1alpha dependency was assessed by...

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Source

Identifiers

PMID: 18376310
DOI: 10.1097/MPA.0b013e31815929fe

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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