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Article

Characterization of Chemoresistance in Pancreatic Cancer: A Look at MDR-1 Polymorphisms and Expression in Cancer Cells and Patients.

International journal of molecular sciences - 4 Aug 2024

Girolimetti Giulia, Balena Barbara, Cordella Paola, Verri Tiziano, Eusebi Leonardo Henry, Bozzetti Maria Pia, Bucci Cecilia, Guerra Flora

Abstract excerpt

Pancreatic malignancy is the fourth cause of cancer-related death in Western countries and is predicted to become the second leading cause of cancer-related mortality by 2030. The standard therapies (FOLFIRINOX and gemcitabine with nab-paclitaxel) are not resolutive because this type of cancer is also characterized by a high chemoresistance, due in part to the activity of the ATP Binding Cassette (ABC) pumps...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxycytidine

Share to Drug Resistance, Neoplasm

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Share to Gene Expression Regulation, Neoplastic

Share to Pancreatic Neoplasms

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Source

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Identifiers

PMID: 39126083
DOI: 10.3390/ijms25158515
PMCID: PMC11312866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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