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Article

Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation.

PloS one - 1 Jan 2011

Paxson Julia A, Gruntman Alisha, Parkin Christopher D, Mazan Melissa R, Davis Airiel, Ingenito Edward P, Hoffman Andrew M

Abstract excerpt

While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX on physiology, morphometry, cell proliferation and apoptosis, global gene expression, and lung fibroblast phenotype and clonogenicity in female C57BL6 mice. The data...

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Identifiers

PMID: 21912590
DOI: 10.1371/journal.pone.0023232
PMCID: PMC3166052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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