Article
No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C.
Annals of hepatology - 1 Jan 2000
Urbánek Petr, Leníček Martin, Muchová Lucie, Subhanová Iva, Dušek Ladislav, Kaspříková Nikola, Hrabal Petr, Bruha Radan, Vítek Libor
Abstract excerpt
BACKGROUND: Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role in oxidative stress defense. OBJECTIVE: To assess the effect of promoter variations of HMOX1 and UGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). MATERIAL AND METHODS: The study was performed...
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