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Article

Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer.

International journal of cancer - 1 Oct 2012

Jirásková Alena, Novotný Jan, Novotný Ladislav, Vodicka Pavel, Pardini Barbara, Naccarati Alessio, Schwertner Harvey A, Hubácek Jaroslav A, Puncochárová Lucie, Šmerhovský Zdenek, Vítek Libor

Abstract excerpt

Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1) enzymes, both involved in bilirubin homeostasis, play an important role in the oxidative stress defense. The objective of our study was to assess the effect of promoter variations of HMOX1 and UGT1A1 genes and of serum bilirubin on the risk of sporadic colorectal cancer (CRC). This exploratory case-control study was based on 777 CRC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 22212955
DOI: 10.1002/ijc.27412

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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