Article
CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2011
Château Alice, van Schaik Willem, Six Anne, Aucher Willy, Fouet Agnès
Abstract excerpt
Capsule and toxin are the major virulence factors of Bacillus anthracis. The B. anthracis pleiotropic regulator CodY activates toxin gene expression by post-translationally regulating the accumulation of the global regulator AtxA. However, the role of CodY on B. anthracis capsulation and virulence of encapsulated strains has been unknown. The role of CodY in B. anthracis virulence was studied in mouse and guinea...
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