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Article

Capsule depolymerase overexpression reduces Bacillus anthracis virulence.

Microbiology (Reading, England) - 1 May 2010

Scorpio Angelo, Chabot Donald J, Day William A, Hoover Timothy A, Friedlander Arthur M

Abstract excerpt

Capsule depolymerase (CapD) is a gamma-glutamyl transpeptidase and a product of the Bacillus anthracis capsule biosynthesis operon. In this study, we examined the effect of modulating capD expression on B. anthracis capsule phenotype, interaction with phagocytic cells and virulence in guinea pigs. Transcriptional fusions of capD were made to the genes encoding heat-shock protein 60 (hsp60) and elongation factor...

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Identifiers

PMID: 20110296
DOI: 10.1099/mic.0.035857-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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