Article
Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis.
Journal of bacteriology - 1 Mar 2013
Château A, van Schaik W, Joseph P, Handke L D, McBride S M, Smeets F M H, Sonenshein A L, Fouet A
Abstract excerpt
In Gram-positive bacteria, CodY is an important regulator of genes whose expression changes under conditions of nutrient limitation. Bacillus anthracis CodY represses or activates directly or indirectly approximately 500 genes. Affinity purification of CodY-DNA complexes was used to identify the direct targets of CodY. Of the 389 DNA binding sites that were copurified with CodY, 132 sites were in or near the...
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