Article
The global nutritional regulator CodY is an essential protein in the human pathogen Streptococcus pneumoniae.
Molecular microbiology - 1 Oct 2010
Caymaris Stéphanie, Bootsma Hester J, Martin Bernard, Hermans Peter W M, Prudhomme Marc, Claverys Jean-Pierre
Abstract excerpt
CodY is a global regulator highly conserved in low-G+C Gram-positive bacteria. It plays a key role in the adaptation of Bacillus subtilis to nutritional limitation through repression of a large gene set during exponential growth and relief of repression upon starvation. In several pathogenic bacteria, CodY regulates major virulence genes. Our interest in Streptococcus pneumoniae CodY originates from our...
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