Article
Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells.
Oncology reports - 1 Feb 2009
Sakurama Kazufumi, Naomoto Yoshio, Ohara Toshiaki, Watanabe Nobuyuki, Takaoka Munenori, Nagatsuka Hitoshi, Tomono Yasuko, Tanida Toru, Noma Kazuhiro, Tanabe Shunsuke, Fujiwara Yasuhiro, Motoki Takayuki, Shirakawa Yasuhiro, Yamatsuji Tomoki, Hirota Seiichi, Taguchi Takahiro, Tanaka Noriaki
Abstract excerpt
There is currently no suitable animal model of metastasis using cultured human gastrointestinal stromal tumor cells even though the molecular mechanisms of c-KIT-mediated progression and metastasis should be clarified. Ba/F3 murine lymphocyte cells transduced with mutant c-KIT have been utilized to analyze some molecular mechanisms related to a constitutively activated c-KIT signaling and to assess the efficacy...
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