Article
Mutation of calcineurin subunit B M118 influences the activities of NF-AT and p53, but not calcineurin expression level.
Biochemical and biophysical research communications - 30 Sept 2011
Cheng Jinbo, Tang Wei, Su Zhenyi, Wei Qun
Abstract excerpt
Calcineurin (CN) is a Ca(2+)/calmodulin-dependent phosphatase, which consists of a catalytic A-subunit (CnA) and a regulatory B-subunit (CnB). Endogenous CnA and CnB have a strong corelationship in cancer cell lines. Through the introduction of CnB and its mutants in cells, we show that CnB does not increase the expression of CnA but protects it from degradation. CnB M118 is necessary for tight binding to CnA....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.