Article
The catalytically active domain in the A subunit of calcineurin.
Biological chemistry - 1 Jan 2000
Xiang Benqiong, Liu Ping, Jiang Guohua, Zou Ke, Yi Fang, Yang Shujie, Wei Qun
Abstract excerpt
Calcineurin (CaN) is a heterodimer composed of a catalytic subunit A (CaNA) and a regulatory subunit B (CaNB). We report here an active truncated mutation of the rat CaNAdelta that contains only the catalytic domain (residues 1-347, also known as a/CaNA). The p-nitrophenyl phosphatase activity and protein phosphatase activity of a/CaNA were higher than that of CaNA. Both p-nitrophenyl phosphatase activity and...
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