Article
Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study.
American journal of nephrology - 1 Jan 2009
Freedman Barry I, Kopp Jeffrey B, Winkler Cheryl A, Nelson George W, Rao D C, Eckfeldt John H, Leppert Mark F, Hicks Pamela J, Divers Jasmin, Langefeld Carl D, Hunt Steven C
Abstract excerpt
BACKGROUND: MYH9 is a podocyte-expressed gene encoding nonmuscle myosin IIA that is associated with idiopathic and human immunodeficiency virus-associated focal segmental glomerulosclerosis (FSGS) and hypertensive end-stage renal disease in African Americans. METHODS: Four single nucleotide polymorphisms comprising the major MYH9 E1 risk haplotype were tested for association with estimated glomerular filtration...
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