An essential member of the HSP70 gene family of Saccharomyces cerevisiae is homologous to immunoglobulin heavy chain binding protein.

doi:10.1073/pnas.87.3.1159

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Article

An essential member of the HSP70 gene family of Saccharomyces cerevisiae is homologous to immunoglobulin heavy chain binding protein.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Nicholson R C, Williams D B, Moran L A

Abstract excerpt

Immunoglobulin heavy chain binding protein (BiP) is present in the lumen of the mammalian endoplasmic reticulum, where it associates transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant proteins that are incorrectly folded. We describe a unique member of the Saccharomyces cerevisiae 70-kDa heat shock protein gene family (HSP70) that encodes a protein...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Carrier Proteins
Endoplasmic Reticulum Chaperone BiP
Genes, Fungal
Genes, Immunoglobulin
Genetic Variation
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin Heavy Chains

Molecular Chaperones

Molecular Sequence Data

Multigene Family

Saccharomyces cerevisiae

Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 2105497
DOI: 10.1073/pnas.87.3.1159
PMCID: PMC53430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2105497-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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