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Article

Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome.

PloS one - 1 Jan 2011

Danielsen Stine A, Cekaite Lina, Ågesen Trude H, Sveen Anita, Nesbakken Arild, Thiis-Evensen Espen, Skotheim Rolf I, Lind Guro E, Lothe Ragnhild A

Abstract excerpt

Colorectal cancer (CRC) is one of the most common cancer types in developed countries. To identify molecular networks and biological processes that are deregulated in CRC compared to normal colonic mucosa, we applied Gene Set Enrichment Analysis to two independent transcriptome datasets, including a total of 137 CRC and ten normal colonic mucosa samples. Eighty-two gene sets as described by the Kyoto Encyclopedia...

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Share to Colorectal Neoplasms
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Genes, Neoplasm

Share to Isoenzymes

Share to Phosphatidylinositols

Share to Phosphoinositide Phospholipase C

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Source

Open in PubMed Open full text

Identifiers

PMID: 21909432
DOI: 10.1371/journal.pone.0024419
PMCID: PMC3164721

Genes

PLCD1
PLCE1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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