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Article

Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014

Satow Reiko, Hirano Tamaki, Batori Ryosuke, Nakamura Tomomi, Murayama Yumi, Fukami Kiyoko

Abstract excerpt

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in CRC predict the ineffectiveness of EGF receptor-targeted therapy. Previous transcriptional microarray analysis suggests the association between phospholipase Cδ1 (PLCδ1) expression and KRAS mutation status in CRC. However, both the roles and the regulatory...

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Source

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Identifiers

PMID: 25197077
DOI: 10.1073/pnas.1405374111
PMCID: PMC4169964

Genes

KRAS
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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