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Article

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2015

Carlile Graeme W, Robert Renaud, Goepp Julie, Matthes Elizabeth, Liao Jie, Kus Bart, Macknight Sean D, Rotin Daniela, Hanrahan John W, Thomas David Y

Abstract excerpt

BACKGROUND: Small molecules as shown by VX809 can rescue the mislocalization of F508del-CFTR. The aim of this study was to identify correctors with a clinical history and their targets of action. METHODS: CFTR correctors were screened using two F508del-CFTR expressing cell based HTS assays. Electrophysiological studies using CFBE41o(-) and HBE cells and in-vivo mouse assays confirmed CFTR rescue. The target of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24974227
DOI: 10.1016/j.jcf.2014.06.001

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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