Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2010

Illek Beate, Lei Dachuan, Fischer Horst, Gruenert Dieter C

Abstract excerpt

BACKGROUND/AIMS: While the Cl(-) efflux assays are relatively straightforward, their ability to assess the efficacy of phenotypic correction in cystic fibrosis (CF) tissue or cells may be limited. Accurate assessment of therapeutic efficacy, i.e., correlating wild type CF transmembrane conductance regulator (CFTR) levels with phenotypic correction in tissue or individual cells, requires a sensitive assay....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Chlorides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Epithelial Cells

Share to Ion Transport

Share to Respiratory Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 21220929
DOI: 10.1159/000324011
PMCID: PMC3221260

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations.PMID 21220929Read ↗

Phenotypic profiling of CFTR modulators in patient-derived respiratory epitheliaSemantic proximity Read ↗

Functional properties of mixed cystic fibrosis and normal bronchial epithelial cell cultures.Semantic proximity Read ↗

Correlation of Electrophysiological and Fluorescence-Based Measurements of Modulator Efficacy in Nasal Epithelial Cultures Derived from People with Cystic Fibrosis.Semantic proximity Read ↗

Relationships among CFTR expression, HCO 3 − secretion, and host defense may inform gene- and cell-based cystic fibrosis therapiesSemantic proximity Read ↗

Correlating genotype with phenotype using CFTR-mediated whole-cell Cl- currents in human nasal epithelial cells.Semantic proximity Read ↗

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.Semantic proximity Read ↗

Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies.Semantic proximity Read ↗

How the sweat gland reveals levels of CFTR activity.Semantic proximity Read ↗

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.Semantic proximity Read ↗

Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-.Semantic proximity Read ↗

CFTR channels in immortalized human airway cellsSemantic proximity Read ↗

Paracellular permeability of bronchial epithelium is controlled by CFTR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.