Gain-of-function of P2X7 receptor gene variants in multiple sclerosis.

doi:10.1016/j.ceca.2011.08.002

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Article

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis.

Cell calcium - 1 Nov 2011

Oyanguren-Desez Olatz, Rodríguez-Antigüedad Alfredo, Villoslada Pablo, Domercq María, Alberdi Elena, Matute Carlos

Abstract excerpt

We have previously shown that P2X7 receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates chronic experimental autoimmune encephalomyelitis. Here, we have explored the putative association of functionally relevant single nucleotide polymorphisms of the P2X7 receptor gene with multiple sclerosis. We found that T allele of rs17525809 polymorphism, which yields an Ala-76 to Val change in...

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PMID: 21906809
DOI: 10.1016/j.ceca.2011.08.002

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