Article
Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.
PloS one - 1 Jan 2013
Itoh Michiko, Kato Hideaki, Suganami Takayoshi, Konuma Kuniha, Marumoto Yoshio, Terai Shuji, Sakugawa Hiroshi, Kanai Sayaka, Hamaguchi Miho, Fukaishi Takahiro, Aoe Seiichiro, Akiyoshi Kazunari, Komohara Yoshihiro, Takeya Motohiro, Sakaida Isao, Ogawa Yoshihiro
Abstract excerpt
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic crown-like structures (hCLS)" in the mouse model of human NASH; melanocortin-4 receptor deficient mice fed a Western...
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