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Article

The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate.

Journal of cardiovascular pharmacology - 1 Mar 2012

Shen Jian, Arnett Donna K, Parnell Laurence D, Lai Chao-Qiang, Straka Robert J, Hopkins Paul N, An Ping, Feitosa Mary F, Ordovás José M

Abstract excerpt

INTRODUCTION: CYP7A1 encodes cholesterol 7α-hydroxylase, an enzyme crucial to cholesterol homeostasis. Its transcriptional activity is downregulated by fenofibrate. The goal of this study was to determine the effect of CYP7A1 polymorphisms on lipid changes in response to fenofibrate. METHODS: We examined the associations of 3 tagging single nuclear polymorphisms (i6782C>T, m204T>G, 3U12536A>C) at CYP7A1 with...

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Identifiers

PMID: 22075751
DOI: 10.1097/FJC.0b013e31823de86b
PMCID: PMC3868459

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