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Article

Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer.

Familial cancer - 1 Jan 2007

Loughrey M B, Waring P M, Tan A, Trivett M, Kovalenko S, Beshay V, Young M-A, McArthur G, Boussioutas A, Dobrovic A

Abstract excerpt

Patients suspected on clinical grounds to have hereditary non-polyposis colorectal cancer (HNPCC) may be offered laboratory testing in order to confirm the diagnosis and to facilitate screening of pre-symptomatic family members. Tumours from an affected family member are usually pre-screened for microsatellite instability (MSI) and/or loss of immunohistochemical expression of mismatch repair (MMR) genes prior to...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

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Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 17453358
DOI: 10.1007/s10689-007-9124-1

Genes

BRAF
MLH1
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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