Article
Pseudomonas evades immune recognition of flagellin in both mammals and plants.
PLoS pathogens - 1 Aug 2011
Bardoel Bart W, van der Ent Sjoerd, Pel Michiel J C, Tommassen Jan, Pieterse Corné M J, van Kessel Kok P M, van Strijp Jos A G
Abstract excerpt
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in mammals and flagellin-sensitive 2 (FLS2) in plants. Activation of these immune systems via flagellin leads eventually to elimination of the bacterium from the host....
Topics
- Animals
- Arabidopsis Proteins
- Bacterial Proteins
- Cattle
- Cell Line
- Endopeptidases
- Flagellin
- Humans
- Immunity, Innate
- Interleukin-8
- Mutation
- NF-kappa B
- Plant Immunity
- Protein Kinases
- Pseudomonas aeruginosa