Profiling early infection responses: <i>Pseudomonas aeruginosa</i> eludes host defenses by suppressing antimicrobial peptide gene expression

Abstract excerpt

Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the model Drosophila melanogaster to dissect and identify early host responses that function in the initiation and progression of Pseudomonas aeruginosa pathogenesis. First, we use immune...

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