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Article

Control of sleep by cyclin A and its regulator.

Science (New York, N.Y.) - 30 Mar 2012

Rogulja Dragana, Young Michael W

Abstract excerpt

How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and...

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Identifiers

PMID: 22461610
DOI: 10.1126/science.1212476
PMCID: PMC3380085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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