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Article

AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking.

Molecular biology of the cell - 15 Jun 2010

Liang Xiubin, Butterworth Michael B, Peters Kathryn W, Frizzell Raymond A

Abstract excerpt

Aldosterone-induced increases in apical membrane epithelial sodium channel (ENaC) density and Na transport involve the induction of 14-3-3 protein expression and their association with Nedd4-2, a substrate of serum- and glucocorticoid-induced kinase (SGK1)-mediated phosphorylation. A search for other 14-3-3 binding proteins in aldosterone-treated cortical collecting duct (CCD) cells identified the Rab-GAP, AS160,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20410134
DOI: 10.1091/mbc.e10-01-0042
PMCID: PMC2883946

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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