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Dilated cardiomyopathy-associated<i>BAG3</i>mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

6 Sept 2011

Abstract excerpt

Dilated cardiomyopathy (DCM) is characterized by dilation of left ventricular cavity with systolic dysfunction. Clinical symptom of DCM is heart failure, often associated with cardiac sudden death. About 20-35% of DCM patients have apparent family histories and it has been revealed that mutations in genes for sarcomere proteins cause DCM. However, the disease-causing mutations can be found only in about 17% of...

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PMID: 21898660
DOI: 10.1002/humu.21603

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