Article

Identification and functional characterization of <i>LDB3</i> gene variants in DCM patients from Indian Population

2025-10-23

Abstract excerpt

The LIM domain-binding protein 3 (LDB3), also known as Z-band alternatively spliced protein (ZASP), is a key component of the Z-disc, essential for maintaining sarcomeric integrity and transmitting contractile force in cardiomyocytes. Genetic variants in LDB3 have been implicated in cardiomyopathies, including dilated cardiomyopathy (DCM). In this study, we have screened 100 idiopathic DCM cases along with control...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a97e8e9-0b50-5f3c-9a41-9a2711019f8e
DOI: 10.1101/2025.10.21.683814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of <i>LDB3</i> gene variants in DCM patients from Indian PopulationDOI 10.1101/2025.10.21.683814Read

Mutations in <i>CSRP3/MLP</i>, a Z-disc associated gene are functionally associated with dilated cardiomyopathy in Indian populationSemantic proximity Read

Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathySemantic proximity Read

A rare form of LIM domain-binding protein 3 (LDB3) mutation causes hypertrophic cardiomyopathy and myofibrillar myopathy type 4.Semantic proximity Read

Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathySemantic proximity Read

Dilated cardiomyopathy-associated<i>BAG3</i>mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytesSemantic proximity Read

The Role of Z-disc Proteins in Myopathy and Cardiomyopathy.Semantic proximity Read

Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z ‐line proteins increase risk of idiopathic dilated cardiomyopathySemantic proximity Read

Analysis of the Z-disc genes PDLIM3 and MYPN in Patients with Hypertrophic CardiomyopathySemantic proximity Read

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type ISemantic proximity Read

Homozygous missense variant in POPDC3 causes recessive limb-girdle muscular dystrophy type 26.Semantic proximity Read

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations.Semantic proximity Read

Integrative in silico analysis identifies functionally and regulatively relevant nsSNPs in the TRIB3 gene.Semantic proximity Read