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Article

MC1R expression in HaCaT keratinocytes inhibits UVA‐induced ROS production via NADPH Oxidase‐ and cAMP‐dependent mechanisms

31 Aug 2011

Abstract excerpt

Ultraviolet A (UVA) radiations are responsible for deleterious effects, mainly due to reactive oxygen species (ROS) production. Alpha-melanocyte stimulating hormone (α-MSH) binds to melanocortin-1 receptor (MC1R) in melanocytes to stimulate pigmentation and modulate cutaneous inflammatory responses. MC1R may be induced in keratinocytes after UV exposure. To investigate the effect of MC1R signaling on UVA-induced...

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PMID: 21898403
DOI: 10.1002/jcp.22996

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