Article
Combinations of SNPs related to signal transduction in bipolar disorder.
PloS one - 1 Jan 2011
Koefoed Pernille, Andreassen Ole A, Bennike Bente, Dam Henrik, Djurovic Srdjan, Hansen Thomas, Jorgensen Martin Balslev, Kessing Lars Vedel, Melle Ingrid, Møller Gert Lykke, Mors Ole, Werge Thomas, Mellerup Erling
Abstract excerpt
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion...
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