Article
A simulated genetic structure for bipolar illness.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Nurnberger John I
Abstract excerpt
Bipolar illness is conceptualized as a polygenic condition. Based on candidate gene findings from the literature to date, up to 22% of the genetic risk in affected persons may be explained by six gene variants with an average allele frequency of 0.59 in cases and 0.54 in controls. The mean allele specific relative risk (ASRR) for these variants is 1.42 (range 1.1-1.8). Initial results from genome-wide association...
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