Article
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder.
Molecular psychiatry - 1 Sept 2009
Pickard B S, Christoforou A, Thomson P A, Fawkes A, Evans K L, Morris S W, Porteous D J, Blackwood D H, Muir W J
Abstract excerpt
The neuronal PAS domain 3 (NPAS3) gene encodes a neuronal transcription factor that is implicated in psychiatric disorders by the identification of a human chromosomal translocation associated with schizophrenia and a mouse knockout model with behavioural and hippocampal neurogenesis defects. To determine its contribution to the risk of psychiatric illness in the general population, we genotyped 70...
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