Article
BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer.
Clinical epigenetics - 27 Nov 2024
Fiegl Heidelinde, Schnaiter Simon, Reimer Daniel U, Leitner Katharina, Nardelli Petra, Tsibulak Irina, Wieser Verena, Wimmer Katharina, Schamschula Esther, Marth Christian, Zeimet Alain G
Abstract excerpt
BACKGROUND: In high-grade ovarian cancer (HGOC), determination of homologous recombination deficiency (HRD) status is commonly used in routine practice to predict response to platinum-based therapy or poly (ADP-ribose) polymerase inhibitors (PARPi). Here we tested the hypothesis that BRCA loss of function (LOF) due to epigenetic or genetic aberrations is a better predictor for the clinical outcome than HRD. One...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.