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Article

BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence

11 Jan 2012

Abstract excerpt

BACKGROUND: The consequences of defective homologous recombination (HR) are not understood in sporadic ovarian cancer, nor have the potential role of HR proteins other than BRCA1 and BRCA2 been clearly defined. However, it is clear that defects in HR and other DNA repair pathways are important to the effectiveness of current therapies. We hypothesize that a subset of sporadic ovarian carcinomas may harbor...

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PMID: 22253870
DOI: 10.1371/journal.pone.0030042

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