Article
Identification of BRCA1-deficient ovarian cancers.
Acta obstetricia et gynecologica Scandinavica - 1 Jun 2011
Skytte Anne-Bine, Waldstrøm Marianne, Rasmussen Anders Aamann, Crüger Dorthe, Woodward Emma R, Kølvraa Steen
Abstract excerpt
OBJECTIVE: It is believed that 24-40% of ovarian cancers have dysfunction in the BRCA1 or BRCA2 (BRCAness) genes, due to either inherited or somatic mutations or due to epigenetic inactivation. Demonstration of ovarian cancers with BRCAness is becoming important both due to the possibility of offering genetic counseling and due to beneficial effects of polyadenosine diphosphate ribose polymerase inhibitor...
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