Article
Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas.
Molecular cancer - 14 Jul 2009
Swisher Elizabeth M, Gonzalez Rachel M, Taniguchi Toshiyasu, Garcia Rochelle L, Walsh Tom, Goff Barbara A, Welcsh Piri
Abstract excerpt
BACKGROUND: DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure. Restoration of BRCA1 and BRCA2 mediates resistance to platinum chemotherapy in recurrent BRCA1 and BRCA2 mutated hereditary ovarian carcinomas. We evaluated BRCA1, BRCA2, and MLH1 protein expression in 115 sporadic primary ovarian carcinomas,...
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