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Article

The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.

International journal of cancer - 15 Feb 2009

Weberpals Johanne, Garbuio Kyla, O'Brien Anna, Clark-Knowles Katherine, Doucette Steve, Antoniouk Olga, Goss Glenwood, Dimitroulakos Jim

Abstract excerpt

This study compares Breast Cancer 1 (BRCA1) and excision repair cross complementation group 1 (ERCC1) expression as predictive markers and evaluates the in vitro enhancement of platinum sensitivity using targeted agents in sporadic ovarian cancer (OC). A retrospective study was performed of advanced stage OC patients receiving platinum-based chemotherapy. BRCA1 and ERCC1 mRNA expression was determined from frozen...

Topics

Adult
Aged
Aged, 80 and over
Antineoplastic Agents
BRCA1 Protein
Carboplatin
Cisplatin
DNA Repair
DNA-Binding Proteins
Endonucleases
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, BRCA1

Genetic Predisposition to Disease

Humans

Middle Aged

Ovarian Neoplasms

Source

Identifiers

PMID: 19035454
DOI: 10.1002/ijc.23987

Genes

BRCA1
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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