Article
The EGFR pathway as an example for genotype: phenotype correlation in tumor genes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Mogck Ulrike, Goekkurt Eray, Stoehlmacher Jan
Abstract excerpt
Tumor-specific and germ-line variations of DNA significantly contribute to tumor growth and its ability to develop resistance. Among several mechanisms that cause resistance to cancer treatment, the genotype of certain growth factors, like epidermal growth factor receptor (EGFR), is critical. EGF...
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