Article
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Da Guoping, Lenkart Jeffrey, Zhao Kehao, Shiekhattar Ramin, Cairns Bradley R, Marmorstein Ronen
Abstract excerpt
The SWIRM domain is a module found in the Swi3 and Rsc8 subunits of SWI/SNF-family chromatin remodeling complexes, and the Ada2 and BHC110/LSD1 subunits of chromatin modification complexes. Here we report the high-resolution crystal structure of the SWIRM domain from Swi3 and characterize the in vitro and in vivo function of the SWIRM domains from Saccharomyces cerevisiae Swi3 and Rsc8. The Swi3 SWIRM forms a...
Topics
- Amino Acid Sequence
- Chromatin
- Conserved Sequence
- DNA
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Protein Structure, Tertiary
- Saccharomyces cerevisiae Proteins