Article
Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.
PLoS genetics - 1 Dec 2008
Norris Anne, Bianchet Mario A, Boeke Jef D
Abstract excerpt
The previously identified LRS (Loss of rDNA Silencing) domain of the nucleosome is critically important for silencing at both ribosomal DNA and telomeres. To understand the function of the LRS surface in silencing, we performed an EMS mutagenesis screen to identify suppressors of the H3 A75V LRS allele. We identified dominant and recessive mutations in histones H3, H4, and dominant mutations in the BAH (Bromo...
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