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Article

Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.

Journal of the American Society of Nephrology : JASN - 1 Jun 2005

Ciarimboli Giuliano, Koepsell Hermann, Iordanova Mariya, Gorboulev Valentin, Dürner Brigitte, Lang Detlef, Edemir Bayram, Schröter Rita, Van Le Truc, Schlatter Eberhard

Abstract excerpt

To elucidate the molecular mechanisms underlying stimulation of rat organic cation transporter type 1 (rOCT1) by protein kinase C (PKC) activation, functional properties and regulation of rOCT1 stably expressed in HEK293 cells after site-directed mutagenesis of putative PKC phosphorylation-sites were compared with wild-type (WT) rOCT1 using microfluorometric measurements with the fluorescence organic cation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15829703
DOI: 10.1681/ASN.2004040256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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