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Article

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2011

Wang Chih-Wen, Lin Hsing-Yi, Shin Shyi-Jang, Yu Ming-Lung, Lin Zu-Yau, Dai Chia-Yen, Huang Jee-Fu, Chen Shinn-Cherng, Li Steven Shoei-Lung, Chuang Wan-Long

Abstract excerpt

BACKGROUND AND AIMS: The adiponutrin/patatin-like phospholipase-3 (PNPLA3) I148M polymorphism has recently been found to contribute to differences in hepatic lipid content. Nonalcoholic fatty liver disease (NAFLD) has recently been considered a hepatic component of insulin resistance and a risk factor in the emergence of type 2 diabetes. However, whether there is an association between PNPLA3 I148M and insulin...

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Identifiers

PMID: 21745282
DOI: 10.1111/j.1478-3231.2011.02526.x

Genes

PNPLA3

Variants

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The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.PMID 21745282Read ↗

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I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

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I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.Semantic proximity Read ↗

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Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea.Semantic proximity Read ↗

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