Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility.

doi:10.1002/hep.32199

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Article

Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility.

Hepatology (Baltimore, Md.) - 1 May 2022

Fairfield Cameron J, Drake Thomas M, Pius Riinu, Bretherick Andrew D, Campbell Archie, Clark David W, Fallowfield Jonathan A, Hayward Caroline, Henderson Neil C, Iakovliev Andrii, Joshi Peter K, Mills Nicholas L, Porteous David J, Ramachandran Prakash, Semple Robert K, Shaw Catherine A, Sudlow Cathie L W, Timmers Paul R H J, Wilson James F, Wigmore Stephen J, Spiliopoulou Athina, Harrison Ewen M

Abstract excerpt

BACKGROUND AND AIMS: Genome-wide association studies (GWAS) have identified several risk loci for gallstone disease. As with most polygenic traits, it is likely that many genetic determinants are undiscovered. The aim of this study was to identify genetic variants that represent new targets for gallstone research and treatment. APPROACH AND RESULTS: We performed a GWAS of 28,627 gallstone cases and 348,373...

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PMID: 34651315
DOI: 10.1002/hep.32199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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