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Article

Protective role of cathepsin L in mouse skin carcinogenesis.

Molecular carcinogenesis - 1 Apr 2012

Benavides Fernando, Perez Carlos, Blando Jorge, Contreras Oscar, Shen Jianjun, Coussens Lisa M, Fischer Susan M, Kusewitt Donna F, DiGiovanni John, Conti Claudio J

Abstract excerpt

Lysosomal cysteine protease cathepsin L (CTSL) is believed to play a role in tumor progression and is considered a marker for clinically invasive tumors. Studies from our laboratory using the classical mouse skin carcinogenesis model, with 7,12-dimethyl-benz[a]anthracene (DMBA) for initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) for promotion, showed that expression of CTSL is increased in papillomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21538579
DOI: 10.1002/mc.20792
PMCID: PMC3155742

Genes

CTSL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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