Article
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Liyanage Udaya K, Goedegebuure Peter S, Moore Todd T, Viehl Carsten T, Moo-Young Tricia A, Larson Justin W, Frey Daniel M, Ehlers Jesmin P, Eberlein Timothy J, Linehan David C
Abstract excerpt
We reported earlier that patients with breast or pancreas cancer have an increased prevalence of regulatory T cells (Treg) in the blood and tumor draining lymph nodes (TDLNs) compared with healthy individuals. In the current study, we tested the hypothesis that tumor cells promote the prevalence of Treg. The transforming growth factor-beta (TGF-beta) secreting murine pancreas adenocarcinoma, Pan02 cell line was...
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