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Article

Fitness landscapes: an alternative theory for the dominance of mutation.

Genetics - 1 Nov 2011

Manna Federico, Martin Guillaume, Lenormand Thomas

Abstract excerpt

Deleterious mutations tend to be recessive. Several theories, notably those of Fisher (based on selection) and Wright (based on metabolism), have been put forward to explain this pattern. Despite a long-lasting debate, the matter remains unresolved. This debate has focused on the average dominance of mutations. However, we also know very little about the distribution of dominance coefficients among mutations, and...

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Identifiers

PMID: 21890744
DOI: 10.1534/genetics.111.132944
PMCID: PMC3213354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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