Article
The molecular basis of dominance.
Genetics - 1 Jan 2000
Kacser H, Burns J A
Abstract excerpt
The best known genes of microbes, mice and men are those that specify enzymes. Wild type, mutant and heterozygote for variants of such genes differ in the catalytic activity at the step in the enzyme network specified by the gene in question. The effect on the respective phenotypes of such changes in catalytic activity, however, is not defined by the enzymes change as estimated by in vitro determination of the...
Topics
- Enzymes
- Genes, Dominant
- Genetic Variation
- Kinetics
- Mathematics
- Models, Genetic
- Molecular Conformation
- Mutation