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Article

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2011

Lee Youngil, Lee Hwa-Youn, Hanna Rita A, Gustafsson Åsa B

Abstract excerpt

The Bcl2/adenovirus E1B 19-kDa interacting protein 3 (Bnip3) is an atypical BH3-only protein that is associated with mitochondrial dysfunction and cell death. Bnip3 is also a potent inducer of mitochondrial autophagy, and in this study we have investigated the mechanisms by which Bnip3 induces autophagy in cardiac myocytes. We found that Bnip3 induced mitochondrial translocation of dynamin-related protein 1...

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Identifiers

PMID: 21890690
DOI: 10.1152/ajpheart.00368.2011
PMCID: PMC3213962

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