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Article

BRCA1 rs799917 and rs1799966 Variants and Breast Cancer Risk in Nigerian Women: A Case-Control Study With Population-Based Allele Frequency Analysis.

Cancer control : journal of the Moffitt Cancer Center - 1 Jan 2026

Oluwabusayo Ogunniyi B, Onyia Abimbola F, Olasehinde Olutola E, Paimo Oluwatomiwa K, Sylvester Divine C, Lasebikan Nwamaka N, Lawal AbdulRazzaq, Alabi Adewumi, Sowunmi Anthonia, Aje Eben A, Shagaya Uchechukwu, Nwachukwu Emmanuella, Oyekan Ademola, Olatunji Temitope, Fatiregun Omolara, Ogo Chidiebere, Nkom Ebenezer S, Omonisi Abidemi E, Popoola Olayinka B, Ahmadu Oiza T, Campos Opeyemi C De, Rotimi Oluwakemi A, Ajibola Toluwanimi O, Anake Timothy A, Aliyu Usman M, Rotimi Solomon O

Abstract excerpt

IntroductionBRCA1 is a tumor suppressor gene involved in DNA repair, genomic stability, and cell cycle regulation. The BRCA1 single nucleotide polymorphisms (SNPs) rs799917 and rs1799966 have been widely investigated for their association with breast cancer (BCa) risk, with inconsistent and population-specific findings. However, their frequency and clinical relevance in Nigerian populations remain poorly...

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Identifiers

PMID: 42461103
DOI: 10.1177/10732748261468805
PMCID: PMC13376491

Genes

BRCA1

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