Article
Genetic variation of αENaC influences lung diffusion during exercise in humans.
Respiratory physiology & neurobiology - 15 Dec 2011
Baker Sarah E, Wheatley Courtney M, Cassuto Nicholas A, Foxx-Lupo William T, Sprissler Ryan, Snyder Eric M
Abstract excerpt
Exercise, decompensated heart failure, and exposure to high altitude have been shown to cause symptoms of pulmonary edema in some, but not all, subjects, suggesting a genetic component to this response. Epithelial Na(+) Channels (ENaC) regulate Na(+) and fluid reabsorption in the alveolar airspace in the lung. An increase in number and/or activity of ENaC has been shown to increase lung fluid clearance. Previous...
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